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Investigation of the dynamics and structure of nanomaterials used in medicine

The present work is devoted to the investigation of the structure and dynamics of nanomaterials by neutron scattering, UV-vis spectroscopy, and dynamic light scattering methods.

Tasks

1. Understanding of the scientific problem.
2. Studying methodologies.
3. Plotting the distributions of cluster sizes by intensity, mass, and volume.
4. Plotting the dependences of optical absorption on wavelengths.
5. Processing of raw-data small-angle neutron scattering spectra.

Preliminary schedule by topics/tasks

The duration of this project is 5 weeks.

Required skills

1. Basic knowledge of condensed matter physics.
2. Basic knowledge of neutron / X-ray scattering methods.
3. Basic knowledge of spectroscopy methods.
4. Computer skills: OriginPro.

Acquired skills and experience

1. Understanding the problems of clusterization of nanoparticles used in medicine.
2. Influence of polarity on the size of aggregates in liquids.
3. Skills at small-angle neutron scattering.
4. Ability to interpret data obtained by UV-vis and DLS methods.

Recommended literature

1. A.I.Kuklin, A.Kh.Islamov, and V.I.Gordeliy. Two-detector System for Small-Angle Neutron Scattering Instrument, Neutron News, 2005, vol. 16, 3, pp.16-18;
2. I. Natkaniec, D. Chudoba, Ł. Hetmańczyk et al. Parameters of the NERA spectrometer for cold and thermal moderators of the IBR-2 pulsed reactor, Journal of Physics: Conference Series, 2014, vol. 554, 012002;
3. Nagorna T., Kuzmenko M., Kyzyma O., Chudoba D., Nagornyi A., Tropin T., Garamus V.M., Jazdzewska M., Bulavin L.: Structural reorganization of fullerene C70 in N-methyl-2-pyrrolidone / toluene mixtures. Journal of Molecular Liquids. 272, 948-952 (2018).
4. Nagorna T.V., Kyzyma O.A., Chudoba D., Nagornyi A.V.: Temporal solvatochromic effect in ternary C70/toluene/N-methyl-pyrrolidine-2-one solution. Journal of Molecular Liquids. 235, 111-114 (2017).
5. Якимова Л.С. Метод УФ-спектроскопии и его применение в органической и физической химии. Казань: Казан. ун-т, 19 с (2015).

Full project description

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